OLSVIS: AN ANIMATED, INTERACTIVE VISUAL BROWSER FOR BIO-ONTOLOGIES

OLSVis: an animated, interactive visual browser for bio-ontologies

Abstract Background More than one million terms from biomedical ontologies and controlled vocabularies are available through the Ontology Lookup Service (OLS).Although OLS provides ample possibility for querying and browsing terms, the visualization of parts of the ontology graphs is rather limited and inflexible.Results We created the OLSVis web a

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A novel CRISPR/Cas9-based iduronate-2-sulfatase (IDS) knockout human neuronal cell line reveals earliest pathological changes

Abstract Multiple complex intracellular cascades contributing to Hunter syndrome (mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the past years.However, the hierarchy of early cellular abnormalities leading to read more irreversible neuronal damage is far from being completely understood.To tackle this issue, we

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